Methodology for urban rail and construction technology research and development planning

A series of transit system visits, organized by the American Public Transit Association (APTA), was conducted in which the system operators identified the most pressing development needs. These varied by property and were reformulated into a series of potential projects. To assist in the evaluation, a data base useful for estimating the present capital and operating costs of various transit system elements was generated from published data. An evaluation model was developed which considered the rate of deployment of the research and development project, potential benefits, development time and cost. An outline of an evaluation methodology that considered benefits other than capital and operating cost savings was also presented. During the course of the study, five candidate projects were selected for detailed investigation; (1) air comfort systems; (2) solid state auxiliary power conditioners; (3) door systems; (4) escalators; and (5) fare collection systems. Application of the evaluation model to these five examples showed the usefulness of modeling deployment rates and indicated a need to increase the scope of the model to quantitatively consider reliability impacts

Experimental and computational characterization of a modified GEC cell for dusty plasma experiments

A self-consistent fluid model developed for simulations of micro- gravity dusty plasma experiments has for the first time been used to model asymmetric dusty plasma experiments in a modified GEC reference cell with gravity. The numerical results are directly compared with experimental data and the experimentally determined dependence of global discharge parameters on the applied driving potential and neutral gas pressure is found to be well matched by the model. The local profiles important for dust particle transport are studied and compared with experimentally determined profiles. The radial forces in the midplane are presented for the different discharge settings. The differences between the results obtained in the modified GEC cell and the results first reported for the original GEC reference cell are pointed out

How to make large, void free dust clusters in dusty plasma under microgravity

Collections of micrometer sized solid particles immersed in plamsa are used to mimic many systems from solid state and fluid physics, due to their strong electrostatic interaction, their large inertia, and the fact that they are large enough to be visualized with ordinary optics. On Earth, gravity restricts the so called dusty plasma systems to thin, two-dimensional layers, unless special experimental geometries are used, involving heated or cooled electrons, and/or the use of dielectric materials.In micro-gravity experiments, the formation of a dust-free void breaks the isotropy of three-dimensional dusty plasma systems. In order to do real three-dimensional experiments, this void has somehow to be closed. In this paper, we use a fully self-consistent fluid model to study the closure of a void in a micro-gravity experiment, by lowering the driving potential. The analysis goes beyond the simple description of the virtual void, which describes the formation of a void without taking the dust into account. We show that self-organization plays an important role in void formation and void closure, which also allows a reversed scheme, where a discharge is run at low driving potentials and small batches of dust are added. No hysteresis is found this way. Finally, we compare our results to recent experiments and find good agreement,but only when we do not take charge-exchange collisions into account

Subbarrel patterns in somatosensory cortical barrels can emerge from local dynamic instabilities

Complex spatial patterning, common in the brain as well as in other biological systems, can emerge as a result of dynamic interactions that occur locally within developing structures. In the rodent somatosensory cortex, groups of neurons called "barrels" correspond to individual whiskers on the contralateral face. Barrels themselves often contain subbarrels organized into one of a few characteristic patterns. Here we demonstrate that similar patterns can be simulated by means of local growth-promoting and growth-retarding interactions within the circular domains of single barrels. The model correctly predicts that larger barrels contain more spatially complex subbarrel patterns, suggesting that the development of barrels and of the patterns within them may be understood in terms of some relatively simple dynamic processes. We also simulate the full nonlinear equations to demonstrate the predictive value of our linear analysis. Finally, we show that the pattern formation is robust with respect to the geometry of the barrel by simulating patterns on a realistically shaped barrel domain. This work shows how simple pattern forming mechanisms can explain neural wiring both qualitatively and quantitatively even in complex and irregular domains. © 2009 Ermentrout et al

Cosmic Microwave Background, Accelerating Universe and Inhomogeneous Cosmology

We consider a cosmology in which a spherically symmetric large scale inhomogeneous enhancement or a void are described by an inhomogeneous metric and Einstein's gravitational equations. For a flat matter dominated universe the inhomogeneous equations lead to luminosity distance and Hubble constant formulas that depend on the location of the observer. For a general inhomogeneous solution, it is possible for the deceleration parameter to differ significantly from the FLRW result. The deceleration parameter $q_0$ can be interpreted as $q_0 > 0$ ($q_0=1/2$ for a flat matter dominated universe) in a FLRW universe and be $q_0 < 0$ as inferred from the inhomogeneous enhancement that is embedded in a FLRW universe. A spatial volume averaging of local regions in the backward light cone has to be performed for the inhomogeneous solution at late times to decide whether the decelerating parameter $q$ can be negative for a positive energy condition. The CMB temperature fluctuations across the sky can be unevenly distributed in the northern and southern hemispheres in the inhomogeneous matter dominated solution, in agreement with the analysis of the WMAP power spectrum data by several authors. The model can possibly explain the anomalous alignment of the quadrupole and octopole moments observed in the WMAP data.Comment: 20 pages, no figures, LaTex file. Equations and typos corrected and references added. Additional material and some conclusions changed. Final published versio

Prospek Jawawut (Pennisetum Spp. ) sebagai Tanaman Pangan Serealia Alternatif

Untuk meningkatkan ketahanan pangan dan diversifikasi pangan, Indonesia dapatmemanfaatkan lahan kering yang cukup luas jumlahnya. Jawawut (Pennisetumspp.) memiliki potensi yang sangat baik sebagai tanaman pangan alternatifditinjau dari aspek kandungan gizi, dan kemampuan tumbuhnya di daerahberiklim kering. Dilihat dari segi kandungan gizinya, jawawut berpotensi sebagaisumber energi, protein, kalsium, vitamin B1, riboflavin (vitamin B2), sedangkannutrisi lainnya setara dengan beras. Potensi hasil yang dapat dicapai di Indonesiaadalah 4 ton per ha pada kondisi agroekologi yang marginal, dimanapertumbuhan serealia lainnya kurang berhasil. Jawawut dipanen sebagai tanamanpangan semusim

Metabolic and hormonal studies of Type 1 (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation

Long-term normalization of glucose metabolism is necessary to prevent or ameliorate diabetic complications. Although pancreatic grafting is able to restore normal blood glucose and glycated haemoglobin, the degree of normalization of the deranged diabetic metabolism after pancreas transplantation is still questionable. Consequently glucose, insulin, C-peptide, glucagon, and pancreatic polypeptide responses to oral glucose and i.v. arginine were measured in 36 Type 1 (insulin-dependent) diabetic recipients of pancreas and kidney allografts and compared to ten healthy control subjects. Despite normal HbA1 (7.2±0.2%; normal <8%) glucose disposal was normal only in 44% and impaired in 56% of the graft recipients. Normalization of glucose tolerance was achieved at the expense of hyperinsulinaemia in 52% of the subjects. C-peptide and glucagon were normal, while pancreatic polypeptide was significantly higher in the graft recipients. Intravenous glucose tolerance (n=21) was normal in 67% and borderline in 23%. Biphasic insulin release was seen in patients with normal glucose tolerance. Glucose tolerance did not deteriorate up to 7 years post-transplant. In addition, stress hormone release (cortisol, growth hormone, prolactin, glucagon, catecholamines) to insulin-induced hypoglycaemia was examined in 20 graft recipients and compared to eight healthy subjects. Reduced blood glucose decline indicates insulin resistance, but glucose recovery was normal, despite markedly reduced catecholamine and glucagon release. These data demonstrate the effectiveness of pancreatic grafting in normalizing glucose metabolism, although hyperinsulinaemia and deranged counterregulatory hormone response are observed frequently

The programming of sequences of saccades

Saccadic eye movements move the high-resolution fovea to point at regions of interest. Saccades can only be generated serially (i.e., one at a time). However, what remains unclear is the extent to which saccades are programmed in parallel (i.e., a series of such moments can be planned together) and how far ahead such planning occurs. In the current experiment, we investigate this issue with a saccade contingent preview paradigm. Participants were asked to execute saccadic eye movements in response to seven small circles presented on a screen. The extent to which participants were given prior information about target locations was varied on a trial-by-trial basis: participants were aware of the location of the next target only, the next three, five, or all seven targets. The addition of new targets to the display was made during the saccade to the next target in the sequence. The overall time taken to complete the sequence was decreased as more targets were available up to all seven targets. This was a result of a reduction in the number of saccades being executed and a reduction in their saccade latencies. Surprisingly, these results suggest that, when faced with a demand to saccade to a large number of target locations, saccade preparation about all target locations is carried out in paralle